Endocrine Abstracts

Objective: To determine if the response to one single dose of 0.5 mg cabergoline (CAB) can be used as predictor for choosing personalized therapy of hyperprolactinaemia. Although CAB is a selective, long half-life D2-receptor agonist some patients proved to be resistant with minimum to no response in serum prolactin and tumour shrinkage, even after a few months of treatment.Patients and methods: A dose of 0.5 mg CAB was administered orally to a number of...

Introduction: As antipsychotic drugs specifically block the D2 receptors, they induce a certain level of prolactin increase, dependent on the time it takes to dissociate from receptors. A recent review (Besnard et al, 2013) mentions that 18% of men and 47% of women treated with antipsychotics for severe mental illness had an increased prolactin level. Even if the long term effects of hyperprolactinemia can be severe, including low bone density, amenorrhea, breast and ...

Introduction: Although for the last 2 decades we have witnessed a rise in the use of second generation antipsychotic treatment in children and adolescents suffering from psychiatric disorders we do not have enough studies in specialty literature to estimate the risks associated with this medication. Recent data and also our clinical experience shows that second generation antipsychotic drugs administration correlates with considerable weight gain and also with altering of gluc...